ISSN 1662-4009 (online)

ey0019.14-7 | Steroidogenesis and beyond | ESPEYB19

14.7. Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

B Ashley , C Simner , A Manousopoulou , C Jenkinson , F Hey , JM Frost , FI Rezwan , CH White , EM Lofthouse , E Hyde , LDF Cooke , S Barton , P Mahon , EM Curtis , RJ Moon , SR Crozier , HM Inskip , KM Godfrey , JW Holloway , C Cooper , KS Jones , RM Lewis , M Hewison , SDD Garbis , MR Branco , NC Harvey , JK Cleal

eLife 2022;11:e71094 doi: 10.7554/eLife.71094Brief summary: Using placental perfusion, placental fragment culture and primary term human cytotrophoblast culture experiments, the authors signify the relationship between maternal vitamin D, placental vitamin D metabolism and fetal vitamin D exposure.In this study, the uptake of radio-labelled vitamin D (13C-25(OH)D...

ey0015.4-11 | New perspectives | ESPEYB15

4.11 Genetic analyses in small-for-gestational-age newborns

SE Stalman , N Solanky , M Ishida , C Alemán-Charlet , S Abu-Amero , M Alders , L Alvizi , W Baird , C Demetriou , P Henneman , C James , LC Knegt , LJ Leon , MMAM Mannens , AN Mul , NA Nibbering , E Peskett , FI Rezwan , C Ris-Stalpers , JAM van der Post , GA Kamp , FB Plötz , JM Wit , P Stanier , GE Moore , RC Hennekam

To read the full abstract: J Clin Endocrinol Metab 2018; 103:917-925SGA is often defined as a birth weight and/or length < −2 SDS for gestational age and gender [43]. A frequent cause of SGA is fetal growth restriction (FGR), often associated with perinatal mortality and morbidity and also implicated in a higher risk of cardio-metabolic disease in adulthood. ...